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Activated caspase-1 enables the N-terminal sequence of cleaved gasdermin D (GSDMD) to bind to the cell membrane to produce membrane pores, leading to cell pyroptosis and release of a large number of inflammatory factors (152)

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Table 1 Summary of clinical studies investigating the combined effects of L-citrulline supplementation and exercise on muscle and vascular function in aging populations

Similarly, chronic stress keeps the body in a state of high oxidative demand

Studied Benefits Post-infarction cardiac repair Preclinical studies in murine models of myocardial infarction have shown that thymosin beta-4 reduces the size of the infarcted area, improves left ventricular contractile function, and stimulates neovascularization of injured cardiac tissue

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