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It is also known as periorbital hyperpigmentation (POH)

it is likely to translate into better real-world adherence, and better adherence is the most important determinant of long-term therapeutic outcomes in chronic disease management

It also binds to metal ions like iron and copper, preventing them from generating more harmful radicals

Its stability drops dramatically the moment it's mixed with a liquid, and at that point, refrigeration isn't just a suggestionit's a non-negotiable requirement

Aranda-Martnez P, Fernndez-Martnez J, Ramrez-Casas Y, Guerra-Librero A, Rodrguez-Santana C, Escames G, Acua-Castroviejo D (2022) The Zebrafish, an outstanding model for biomedical research in the field of melatonin and human diseases

Atkins MB, Lotze MT, Dutcher JP, Fisher RI, Weiss G, Margolin K et al