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This specificity comes from growth hormone direct lipolytic action on visceral adipocytes, which express higher concentrations of growth hormone receptors than subcutaneous fat cells

Whilst the market is currently led by Novo Nordisks semaglutide (Ozempic/Wegovy) and Eli Lillys tirzepatide (Mounjaro/Zepbound), stronger competition is expected as new entrants including Boehringer Ingelheim, Amgen, Pfizer and Roche offer novel mechanisms (dual agonists, triple agonists and amylins), formulations (oral vs injectable) and dosing regimens (daily vs weekly vs monthly)

The pancreatic volume was smaller and pancreatic fat content was increased in patients with T2DM than the normal subjects

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Several pathways mediate this action by rapid, kinase phosphorylation-dependent, but gene expression-independent mechanisms