Belonging to the class of drugs called GLP-1 receptor agonists, semaglutide works by mimicking the function of a hormone in the body known as glucagon-like peptide-1 (GLP-1)
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They work by targeting the GIP and GLP-1 receptors in the brain's appetite control centers, including the hypothalamus [17, 18]
Moreover, distinct cytokine signatures have been associated with varying severity levels of ME/CFS, where higher levels of plasma pro-inflammatory cytokines, such as colony-stimulating factor 2 (CSF2), correlate with increased physical and fatigue symptoms in these patients (Giloteaux et al., 2023)
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