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Of great importance, opposite regulation of key pro-fibrotic marker genes -smooth muscle actin ( ACTA2 ) and connective tissue growth factor ( CTGF ) by aloxistatin in TGF1-stimulated HCFs derived from both ICM and DCM patients could be validated using qPCR (Fig

Differential gene expression analysis was performed using Seurats FindMarkers function, which performs differential expression based on the nonparametric Wilcoxons rank-sum test

Generally, the term peptide refers to a protein that consists of just one polypeptide chain no longer than 40 or 50 residues

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This semisolid formulation is dispensed through a pump mechanism, which ensures ease of use and precise dosing

For example, after a traumatic brain injury (TBI), thrombin influx into the injury site creates a localized hotspot that can be used to attract NPs that are modified with a peptide (CAQK) capable of binding specifically to thrombin in the affected area