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Description

Gmez-Valero, M

Common adverse effects include nausea, vomiting, diarrhoea, constipation, and abdominal pain , particularly during the dose escalation phase (starting at 0.25 mg and gradually increasing to 2.4 mg over several weeks)

This systemic action is what makes timing so important

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FEBS J (2012) 279(8):137585.10.1111/j.1742-4658.2012.08551.x 206 BeggiatoSAntonelliTTomasiniMCTanganelliSFuxeKSchwarczRet alKynurenic acid, by targeting 7 nicotinic acetylcholine receptors, modulates extracellular GABA levels in the rat striatum in vivo