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71 Acyl-CoA synthetase long-chain family member 4 (ACSL4) and lysophosphatidylcholine acyltransferase 3 (LPCAT3) were firstly identified as key enzymes which promote PUFAs into PLs for forming PL-PUFAs and induce ferroptosis

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Excess glucose in circulation interacts with the microvascular and endothelial dysfunction caused by hyperglycemia is strongly associated with inflammatory signaling and oxidative stress