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The 4-Hour Rule: Supplements containing calcium, iron, or magnesium can significantly interfere with the absorption of levothyroxine

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Immunity 42 , 4154 (2015)

Mitochondrial impairment serves as a key driver of ferroptosis by elevating reactive oxygen species and promoting the iron-mediated Fenton process, wherein ferrous ions facilitate the transformation of hydrogen peroxide into highly reactive hydroxyl radicals, thereby exacerbating oxidative damage and triggering ferroptotic cell death (121, 125, 126)

Many people experience weight regain after stopping diet or exercise regimens

Less Common Mild headache Temporary skin purging (topical) These typically resolve with continued use or dose adjustment