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In unstressed cells, ASK1 is complexed with redox-active thioredoxin, but under many stress conditions, an accumulation of hydrogen peroxide oxidizes thioredoxin to release ASK1 [146]

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After 1 year of treatment, the average weight loss with semaglutide was 14.6 kg, or 14.1% of body weight, while the average weight loss with Tirzepatide was 17.2 kg, or 16.5% of body weight