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The impact of allicin on blood pressure and renal function was comparable to that of losartan in rats with chronic kidney disease, and the antihypertensive effect of allicin was associated with the upregulation of angiotensin II receptor type 2 (AT2R) and endothelial nitric oxide synthase (eNOS) as vasodilators [51]

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Occasionally, patients may experience mild gastrointestinal upset or headache related to the niacinamide component