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Metformin, a first-line T2DM treatment, affects the gastrointestinal tract by altering glucose uptake, GLP-1 secretion, gut microbiota, and immune response [33, 34], but it rarely causes bowel obstruction

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This prevents both muscle loss and follicle starvationtwo processes that cascade into visible shedding

The Journal of clinical investigation 123 , 36643671, doi:10.1172/JCI67230 (2013)

& Probstfield, J

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