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The primary actions of secretin include induction of bile secretion from the gallbladder into the duodenum, enhanced secretion of bicarbonate and H 2 O into the duodenum from the pancreas, and increased gastric pepsin secretion

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Caco-2 cells were grown in Minimal Essential Medium with Earles Balanced Salts (MEM/EBSS, Cytiva) medium supplemented with 10% fetal bovine serum and 1% penicillinstreptomycin and 25 mM HEPES