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How GLP-1 receptor agonists can promote weight loss GLP-1 receptor agonists mimic a natural hormone our intestines release called glucagon-like peptide 1, which can promote weight loss via three actions: Suppressing appetite "The drugs 'talk' to our brain to encourage us to eat less and to be less preoccupied with food," explains Alexandra Sowa, MD , a dual board-certified obesity and internal medicine physician practicing in New York City, a clinical instructor of medicine at New York University, and author of The Ozempic Revolution

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GLP-1 peptides bind to the GLP-1 receptor , which is expressed in the brain, pancreas, and gastrointestinal tract