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Conversely, a panel of genes that promote fatty acid oxidation was induced 2~3 fold in these same mice

So far, multiple PD-associated genes have been identified, including SNCA , LRRK2 , PINK1 , Parkin , DJ-1 and GBA1

60 In hepatoma cells, miR-125b-5p directly targets the downstream gene STAT3 to enhance -catenin phosphorylation

Other groups found similar outcomes that linked the GPx3 locus to ALS but were also able to demonstrate that lower GPx3 levels strongly correlated with more advanced disease, in addition to showing significant motor deficits in a knockdown zebra fish model 21

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