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Several contraindications and precautions must be considered to ensure patient safety: Allergic Reactions: Patients who have had an allergic reaction to semaglutide or any of its components should not use this medication

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The tirzepatide evidence base Tirzepatide's clinical record centers on the SURMOUNT program for weight management ( The New England Journal of Medicine , 2022) and SURMOUNT-OSA for obstructive sleep apnea (NEJM 2024)

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In contrast, 3-methylcholanthrenetype inducers have less of a tendency to increase liver weight and do not appreciably increase smooth endoplasmic reticulum