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Six participants cannot define a treatment effect A crossover design can be useful for exploratory research, but a study involving six people cannot establish uncommon risks, long-term effectiveness or suitability for people with different health conditions

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Oncogene 40 , 23392354 (2021)

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One of the primary symptoms of Graves Disease is hyperthyroidism, characterised by rapid heartbeat, weight loss, and increased sensitivity to heat

In particular, USP22 raised GSH content and reduced the occurrence of ferroptosis in cardiomyocytes by activating the Sirt1-p53/SLC7A11 axis [252]