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These reactions are unrelated to time of day but can be minimized through proper injection technique, site rotation, and ensuring medication reaches room temperature before administration

In short, MTHFR initiates the conversion of folate (vitamin B9) to its functional form 5-methyltetrahydrofolate 93,94 , which on its turn acts as a coenzyme of methionine synthase for the formation of methionine from homocysteine 93,94

doi: 10.1021/jm070861j 83 WildingJPHOvergaardRVJacobsenLVJensenCBle RouxCW