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In contrast to findings with behavioral 20,21,22 and other pharmacological interventions 10,12,13 , the similar mean weight loss achieved with semaglutide 2.4 mg in STEP 5 at weeks 52 and 104 (15.6% and 15.2%, respectively) suggests that, on average, there is minimal weight regain over 104 weeks when once-weekly semaglutide therapy is continued

Same clinical standards

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In states with full practice authority, NPs can prescribe semaglutide independently after completing appropriate training

That single finding is what reassured the field that a triple agonist could be both potent and metabolically sensible

Doyle SL, Donohoe CL, Lysaght J, Reynolds JV