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Diagn Pathol

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In the last recent years, the association between low serum levels of A1AT and the development of RA has been identified, particularly in relation to specific A1AT genotypes

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Changes in their levels may serve as potential biomarkers for the early diagnosis and prognosis of this disease

Under physiological conditions, the Neh2 structural domain of Nrf2 binds to Kelch-like ECH-associated protein 1 (Keap1) in the cytoplasm, facilitating Nrf2 ubiquitination and subsequent degradation (32)