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The research outcomes highlight the importance of continuous patient safety checks while GLP-1RAs are administered [58]

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A2AR inhibition of D2R signaling regulates striatal glutamatergic transmission dysfunction via increasing the extracellular glutamate levels (119) and promotes microglia-mediated neuroinflammation (120)

Like all medications, semaglutide can have side effects

Regular monitoring : Track weight, measurements, and non-scale victories (improved energy, better sleep, reduced medication needs for comorbidities)

Collectively, these actions benefit cardiovascular health, as has been demonstrated in recent cardiovascular outcome trials using various GLP1 mimetics (Marso, Bain, et al., 2016