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In addition, other strategies have also been developed to enhance the lymph node-targeted vaccination, including the pullulan nanogel system (240), synthetic vaccine nanoparticles (239), LN-targeted lipid nanoparticles (242, 245), and LN-targeted immunization formulation (244, 246, 247)

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Prolonged receptor activation through long-acting design: Native amylin is rapidly cleared from circulation, limiting its biological effect

The bilayer fluidity was higher in the case of cationic liposomes