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However, an unphysiologically large postprandial release of GLP1, for example, after gastric bypass surgery (Korner et al., 2007), might reach the circumventricular organs, and DPP4resistant GLP1 receptor agonists clearly have central actions, though whether this includes action on GLP1 receptors inside the BBB or is limited to direct activation of GLP1 receptors in the circumventricular organs outside the BBB, is less clear (Adams et al., 2018

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GLP-1R distribution in the cardiovascular system GLP-1R is a member of the class B1 family of G protein-coupled receptor for which there are only predicted structures [30]

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Some GLP-1 RAs (like semaglutide) might even interfere with certain lab tests for B12, so doctors need to be aware of that

doi: 10.2146/ajhp050459 48 SimonsenLHolstJJDeaconCF