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The researchers found that when the drug stimulated the brains central melanocortin system, the rat models lost body mass independent of a reduction in caloric intake

In addition, the increased expression and activity of NOX and xanthine oxidase and NOS becoming uncoupled and structurally unstable also lead to increased ROS production [8]

The maximum serum drug concentration ( C max ) and its corresponding time ( T max ) were determined by visual inspection of the concentration-time curve

doi:10.3389/fneur.2020.589605 Han W, Fan Z, Zhou M, et al

Arch Acad Emerg Med

10.3390/jpm11080784 50 SahaS.SahaT.RajammaU.SinhaS.MukhopadhyayK