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This distinction may be attributed to the fact that the afferent pathway stimulated by auricular vagal nerve does not traverse the cervical vagus nerve

Beyond weight reduction, the same trial reported several additional metabolic outcomes as secondary or exploratory endpoints: Improved glycaemic control reductions in HbA1c levels were observed in participants with type 2 diabetes in a separate Phase 2 cohort [3] [4] Reduced waist circumference suggesting a decrease in visceral (abdominal) fat, which is associated with cardiovascular risk Improvements in lipid profiles including reductions in triglycerides Potential signal for benefit in metabolic-associated steatotic liver disease (MASLD) based on the glucagon receptor's proposed role in hepatic fat metabolism

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While low-dose paraxanthine showed a trend toward improvement in older animals, it didn't reach statistical significance (p = 0.07)

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