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Probiotics exhibit antidepressant properties in the absence of other therapeutic options (Nikolova et al., 2021)

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Nonetheless, early evidence did suggest that mechanisms sensitive to loop diuretics, possibly involving NKCC1 and/or KCCs, may contribute to the phosphorylation of numerous protein substrates in the liver (Lang et al., 1998)

It is not metabolized by hepatic cytochrome P450 (CYP) enzymes

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