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Melatonin utility in neonates and children

Under the conditions of unilateral ureteral obstruction and renal ischemia/reperfusion injury, tubular necroptosis is markedly upregulated, which in turn promotes NOD-like receptor protein 3 (NLRP3) inflammasome activation leading to renal fibrosis

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As expected, the overexpression of PCBP1 and PCBP2 significantly inhibited the ability of ACE to increase lipid peroxidation and Fe 2+ , which further confirmed our speculation (Fig