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A liquid pharmaceutical composition consisting of a) 0.5-10 mg/ml semaglutide, optionally b) no more than 0.1 %(w/w) phenol, c) 8.1-8.9 mg/ml sodium chloride, d) buffer, e) at least 60% water, optionally g) one or more agents for adjusting pH, such as HCI, NaOH, or acetate, and said composition optionally has a pH of 6-10 such as 7-8

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AGEs/RAGE stimulation activates immune cells, resulting in NADPH oxidase (NOX) overexpression, which is a primary cytoplasmic source of free radicals and pro-inflammatory factors such as tumor necrosis factor- (TNF-), interleukin 1 (IL-1) and interleukin 6 (IL-6) 5,6,7,8

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However, genetic predisposition does not predict exact medication or peptide responsethese variants should be interpreted with a qualified healthcare provider as one piece of a comprehensive wellness assessment