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These translational findings are an outgrowth of a mechanistic model in rodents with impaired plasticity of key brain areas relevant to mood, cognitive and other main disorders, wherein LAC levels are markedly decreased and signal abnormal brain and systemic functions

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The phase 3 randomized withdrawal trial evaluated the long-term efficacy of tirzepatide for weight maintenance in adults with obesity or overweight

Lancet Diabetes endocrinol (2020) 8(5):37791

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doi: 10.1186/1757-2215-6-41 92 HuLLiHLeeEDGrandisJRBaumanJEJohnsonDE