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GLP-1 receptor agonists such as semaglutide (Ozempic and Wegovy), and tirzepatide (Mounjaro and Zepbound) have been most commonly associated with gastrointestinal side effects, such as nausea, vomiting, diarrhea and constipation

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File the appeal within the stated deadline, and consider requesting your physician's office involve a peer-to-peer review, where your doctor speaks directly with the BCBS medical director reviewing the case

Phase 3 outcomes will be critical to confirm sustained efficacy, cardiovascular benefit, tolerability at scale, and real-world adherence

This includes conducting large-scale, multi-center prospective validation studies that comply with established guidelines and assess clinically meaningful outcomes, such as reduced mortality, complications, or hospital stay