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Why pulsatile and endogenous matters Because these analogs stimulate the pituitary rather than replacing GH, the resulting secretion tends to preserve the bodys natural pulsatile rhythm and remains subject to normal feedback control somatostatin, IGF-1 negative feedback, and the finite secretory capacity of the gland

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Notable examples include hepatocellular carcinoma, cancers of the gallbladder and biliary tract, gastric adenocarcinoma, colorectal cancer, and prostate cancer