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Discussion Inflammation and angiogenesis are widely recognized as critical orchestrators in tumour insurgence and progression [46]

The statistical significance was determined by unpaired two-tailed Students t-test for two-group comparisons and by one-way ANOVA followed by Bonferronis multiple-comparisons test for multi-group comparisons using R (v.3.6.0, P values of 1.5 or 0.05, Figure 4C )