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This explainer will give you a brief overview of the issues and then summarize some recent publications the benefits and costs of drugs like semaglutide and tirzepatide

Semaglutide effects on cardiovascular outcomes in people with overweight or obesity (SELECT): outcomes by sex

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Schneider-Helmert et al

5.2 Alterations on other gut microbiota-derived metabolites Flaxseed oil intervention modulated the microbial bile acids (BAs) metabolism in feces while exhibited anti-atherosclerosis action on high-fat diet-induced ApoE / mice, showing increases of lithocholic acid, allocholic acid, glycocholic acid, and taurocholic acid and decreases of allolithocholic acid, isolithocholic acid, 7-ketodeoxycholic acid, -ursodeoxycholic acid, chenodeoxycholic acid, and hyodeoxycholic acid (58)

In this review, we summarize several drugs and inhibitors that specifically target Gln metabolism