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The absolute risk difference is small, but the relative doubling is consistent across multiple trials

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The most frequently reported adverse events were gastrointestinal events, including nausea, vomiting, diarrhea, constipation, or abdominal pain, which affected 79.6% of participants in the cagrilintide-semaglutide group and 39.9% of those in the placebo group

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These results are consistent with findings from TRIUMPH-4, another branch of the program that specifically assessed knee osteoarthritis as an indication