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[40] In September 2025, the US Food and Drug Administration (FDA) initiated the process of approving leucovorin calcium tablets for the treatment of cerebral folate deficiency, a condition associated with developmental delays, autistic features, seizures, and movement issues

Returning to our primary dataset, we found that in certain conditions such as CF and FTD, over 20% of recent trials incorporated digital componentsa proportion higher than the reported 11% adoption rate in trials for common neurological disorders in 2020 35

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