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They are often used in conjunction with xanthine oxidase (XO) inhibitors or prescribed for patients who cannot tolerate XO inhibitors

If levels of glutathione are low, the levels of free radicals increase

Disulfide bonds formed by the oxidation of two cysteine residues to give cystine are essential for the stability of secreted and plasma-membrane proteins (reviewed in Trivedi et al , 2009)

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Restoration of correct splicing in thalassemic pre-mRNA by antisense oligonucleotides

Adequate levels of vitamin B12 are also required for a healthy nervous system, pregnancy, and the ability to produce DNA