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While multiple randomized controlled trials (RCTs) have confirmed the short-term efficacy and safety of GLP-1 RAs, the long-term outcomes, particularly regarding sustained weight loss, weight regain, and safety profiles, remain areas of active investigation [6]

But these free radicals can be neutralized by antioxidants

Metabolism Adapts and Slows When you restrict calories, your metabolism downshifts to conserve energy making each pound harder to lose and easier to regain

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[12] Pati, S., Irfan, W., Jameel, A., Ahmed, S., & Shahid, R

They are also claimed to increase levels of adiponectin, a hormone that helps to regulate metabolism