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The hallmark symptom of acute pancreatitis is severe, persistent abdominal pain , typically located in the upper abdomen (epigastric region) and often described as: Sudden onset and constant (not cramping or intermittent) Severe intensity that may worsen after eating Radiating through to the back or between the shoulder blades Accompanied by a tender abdomen when touched Associated symptoms that frequently occur alongside the abdominal pain include: Nausea and persistent vomiting Fever and rapid pulse Abdominal swelling or distension Loss of appetite Feeling generally unwell (malaise) It is crucial to distinguish pancreatitis symptoms from the common gastrointestinal side effects of GLP-1 agonists, which affect a significant proportion of users, particularly during treatment initiation

N-terminal acetylation and the N-end rule pathway control degradation of the lipid droplet protein PLIN2

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their chondrogenic potential), making them less suitable for tissue engineering purposes

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Within this core group of 10 protease families, a multitude of proteases evolved to yield intra- and extra-cellular processes