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Neuroprotective Potential: Preclinical and early clinical research suggests GLP-1 may have protective effects on the brain

J Affect Disord 2011;135:389-94

According to a phase 3 clinical trial, a once-weekly injection of retatrutide can significantly improve blood sugar levels and lead to substantial weight loss in people with type 2 diabetes

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Infiltration of M1-type macrophages into visceral fat leads to chronic release of pro-inflammatory cytokines, such as IL-1, which drive ovarian interstitial fibrosis and hemodynamic changes (62, 63)