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Hyperammonemic encephalopathy in an adenocarcinoma patient managed with carglumic acid

doi: 10.1038/srep37664

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Initially approved for glycemic control in type 2 diabetes mellitus, their clinical application has expanded into obesity management, cardiovascular risk reduction, and metabolic syndrome modulation

However, both medications work best when combined with a low-calorie diet and regular physical activity, as lifestyle changes remain the foundation of weight management

These potential contributing factors should be considered alongside other common causes of cold extremities