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Those who took GLP-1s for less than 18 months before discontinuing saw no significant risk reduction compared to the group on sulfonylureas at the end of the trial
It should be avoided or used only under clinician supervision in patients with kidney disease, older adults, or those at risk for electrolyte abnormalities , due to the risk of hypermagnesemia., Use sparingly: Stimulant laxatives (such as bisacodyl or senna) may be effective for intermittent rescue use , but they can cause cramping and are generally not needed for routine long-term management when osmotic agents are effective., Safety note: Regular stimulant laxative use that causes frequent loose stools may contribute to dehydration and electrolyte imbalance (including hypokalemia) and should therefore be intermittent unless clinician-directed . What about docusate (Colace)
Both can be effective for losing weight, but only Wegovy is approved for it
CMS will use that data to inform whether to make GLP-1 weight management coverage permanent under Medicare
GLP-1 medications are different from older classes of prescription weight loss medications (like phentermine) because they work on key underlying metabolic pathways to support sustained weight loss
