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It is triggered by the GTPases mitofusin 1 (Mfn1) and mitofusin 2 (Mfn2), located in the OMM

Recent data support that this concept is operative in vivo , showing that Nox1 overexpression in vascular smooth muscle cells resulted in increased vascular oxidative stress and eNOS uncoupling, which could be reversed by BH 4 supplementation

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However, the significance of these findings is difficult to assess without a control group for comparison

Therapeutic peptides are often administered via injection because they degrade easily in the digestive tract and have low bioavailability when taken orally