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Two milliliters of digestive solution [4 mL of 2 g/mL Dispase (Corning, 354235) and 40 L of 0.05 mg/mL DNase I (Sigma, DN25)] was then quickly instilled through the trachea into the lungs, after which the trachea was tied off

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To determine the degree of adherence to treatment (and thus avoid outcome dilution effects) [41], the number of doses taken orally and received by injection will be recorded