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Again, surgery is still important in these cases to prevent the condition from getting worse

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Here we investigate the allosteric regulation of the mammalian glutamate dehydrogenase GDH and show how the Guanosine triphosphate (GTP) binding establishes allosteric communication with the regulatory coenzyme NADH which then synergistically inhibits the oxidative deamination activity of GDH by stabilizing its closed conformation

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Newly made proteins usually must fold from a linear chain of amino acids into a three-dimensional form