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Components of metabolic syndrome, lipid and hepatic panels, adiposity, oxidative stress and inflammation biomarkers We measured the components of metabolic syndrome, lipid panel, hepatic panel and adiposity, oxidative stress, and inflammation biomarkers within three weeks before 4-week intermittent fasting, at the end of 4-week intermittent fasting during 4-week intermittent fasting, and 1 week after 4-week intermittent fasting

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Localised Autocrine/Paracrine Activity IGF-DES produces rapid and localised IGF-1R activation with a shorter activity period

Possible side effects of IGF-1 DES can include [1, 16]: Impaired glucose metabolism and hypoglycemia Fatigue Changes in sexual function Swelling of soft tissues Hyperandrogenism Muscle and joint pain Fluid retention Gynecomastia Orthostatic hypotension One of the more serious side effects of prolonged IGF-1 DES administration is acromegalic cardiomyopathy (enlargement and weakening of the heart)