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For optimal GH response: Morning (fasted): Mimics natural morning GH surge Post-workout: Enhances recovery and IGF-1 response Before bed: Aligns with deep sleep GH release Avoid taking it immediately after meals, as insulin blunts GH secretion

Mol Psychiatry (2017) 22:32835

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Collectively, the evidence presented suggests that melatonins ability to mitigate AD may involve the modulation of whole-body insulin pathways, including the brain