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Mone P, Lombardi A, Kansakar U, Varzideh F, Jankauskas SS, Pansini A, et al
Hence they stimulate the accumulation of lipid intermediate metabolites [lysophosphatidic acid (LPA), diacylglycerol (DAG), acylcarnitines and ceramides], which promote defects of the insulin signaling pathway, exacerbate IR and stimulate several signaling pathways related to inflammation and oxidative stress, creating a second vicious-cycle of a feed-forward effect [17, 2123]
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[DOI] [PubMed] [Google Scholar] 25.Matthews J.E., Stewart M.W., De Boever E.H., Dobbins R.L., Hodge R.J., Walker S.E
In clinical trials, the drugs have led to patients losing up to 18 percent of their bodyweight compared to a placebo (1)
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