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This strategy, explored over the last two decades, has recently been successful using GST-activated nitrogen mustard (TLK286) and GT-activated arsenic-based (GSAO and Darinaparsin) prodrugs confirming the potential of GSH-conjugates as anticancer drugs

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Plasma extracellular vesicle proteomic profiling showed unique protein changes in immune-related pathways and T cell functions

complaints can include fatigue, weakness, weight loss, loss of appetite, nausea, abdominal pain, jaundice, itching, edema and sometimes mental confusion

doi: 10.1159/000486129 18 GraafCDonnellyDWoottenDLauJSextonPMMillerLJet al