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doi: 10.1029/2000JE001413 129 ZolotovM

December 2023)

The Semaglutide Family: Complete Overview Tirzepatide (Mounjaro) vs Semaglutide (Wegovy): The Mechanism Difference The clinical reason Mounjaro produces greater weight loss than Wegovy is its dual mechanism: Wegovy (semaglutide) GLP-1 agonism only Semaglutide activates GLP-1 receptors stimulating insulin secretion, suppressing glucagon, slowing gastric emptying, and activating appetite-suppressing pathways in the hypothalamus

Advantage : Amycretin Safety Profile# Amycretin : GI adverse events most common, consistent with GLP-1/amylin class