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Delta SleepInducing Peptide (DSIP) directly targets hypothalamic sleep centers, increasing deltawave activity, shortening sleep latency, and modulating nighttime cortisol spikes

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Many of these studies, however, are correlative

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To enhance sensitivity, specificity, and translational relevance, future research should incorporate multimodal biomarker strategiescombining imaging, fluid-based, and multi-omics analyses