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2009;297(2):E552-559 Horowitz JF, Klein S

These are population-level estimates and individual needs vary considerably

It matters for strength, metabolic health, balance, exercise tolerance, and long-term weight maintenance

This lines up with what we see physiologicallyGLP-1 seems to shift autonomic balance toward sympathetic dominance, which fitness can partly buffer at the level of heart rate but not at the deeper vagal modulation reflected in HRV